jneuroJournal of Neurology and NeuropsychiatrycoVolume 1 Issue 2 (July-Dec)MultidisciplinaryEnglish6 Months NNY20241121NeurologyCase Study of NMDA Encephalitis in an 18-Year-Old Female With No Underlying Etiolog.EnglishY410SabinaNayab1EnglishNQasimBashir2EnglishYAdnanAslam3EnglishYAmina Saeedkhan4EnglishYBackground: Anti-NMDA receptor encephalitis is a rare autoimmune disorder caused by the formation of antibodies against NMDA receptors in the brain. Symptoms can include confusion, hallucinations, seizures, memory loss, and difficulty speaking, as well as autonomic dysfunction and movement disorders.Case Presentation: The case presented is of an 18-year-old female patient who presented with altered behavior, low-grade fever, and rigidity. The patient was diagnosed with NMDA encephalitis based on elevated protein levels, lymphocytes pleocytosis, and positive NMDA antibodies in serum. The patient was treated with pulse therapy with injection Solumedrol and IVIGs, leading to significant improvement. No underlying cause for the encephalitis was identified.Conclusion: The diagnosis is typically made through a combination of clinical findings, laboratory tests, and imaging studies, and the detection of anti-NMDA receptor antibodies in the cerebrospinal fluid (CSF) and serum. Treatment typically involves immunotherapy, such as steroids or plasma exchange, and treatment of any underlying infection or tumor. Prognosis varies based on the severity of the disorder and timing of treatment, with early diagnosis and treatment leading to better outcomes. This case highlights the importance of early diagnosis and treatment of anti-NMDA receptor encephalitis for a better outcome.EnglishNMDA encephalitis, Anti NMDA receptorhttps://jneuro.clsconf.com/admin/abstract?id=24References1619ReferencesWang HY, Li T, Li XL, Zhang XX, Yan ZR, Xu Y. Anti-N-methyl-D-aspartate receptor encephalitis mimics neuroleptic malignant syndrome: case report and literature review. Neuropsychiatric Disease and Treatment. 2019;15(1):773-778. Doi: https://doi.org/10.2147/NDT.S195967Huang Q, Xie Y, Hu Z, Tang X. Anti-N-methyl-D-aspartate receptor encephalitis: a review of pathogenic mechanisms, treatment, prognosis. Brain Research. 2020;1727(1):146549. Doi: https://doi.org/10.1016/j.brainres.2019.146549Chiu HC, Su YC, Huang SC, Chiang HL, Huang PS. Anti-NMDAR encephalitis with ovarian teratomas: review of the literature and two case reports. Taiwanese Journal of Obstetrics and Gynecology. 2019;58(3):313-317. Doi: https://doi.org/10.1016/j.tjog.2019.03.005Nan D, Zhang Y, Han J, Jin T. Clinical features and management of coexisting anti-N-methyl-D-aspartate receptor encephalitis and myelin oligodendrocyte glycoprotein antibodyand;ndash;associated encephalomyelitis: a case report and review of the literature. Neurological Sciences. 2021;42(3):847-855. Doi: https://doi.org/10.1007/s10072-020-04979-2Forrester A, Latorre S, Oand;#39;Dea PK, Robinson C, Goldwaser EL, Trenton A, Tobia A, Aziz R, Dhawan S, Brennan A, Kurukumbi M. Anti-NMDAR encephalitis: a multidisciplinary approach to identification of the disorder and management of psychiatric symptoms. Psychosomatics. 2020;61(5):456-466. Doi: https://doi.org/10.1016/j.psym.2020.05.010Yang S, Yang L, Liao H, Chen M, Feng M, Liu S, Tan L. Clinical characteristics and prognostic factors of children with anti-N-methyl-D-aspartate receptor encephalitis. Frontiers in Pediatrics. 2021;9(1):605042. Doi: https://doi.org/10.3389/fped.2021.605042Zhu J, Li Y, Zheng D, Wang Z, Pan S, Yin J, Wang H. Elevated serum and cerebrospinal fluid CD138 in patients with anti-N-methyl-d-aspartate receptor encephalitis. Frontiers in Molecular Neuroscience. 2019;12(1):116. Doi: https://doi.org/10.3389/fnmol.2019.00116Barry H, Byrne S, Barrett E, Murphy KC, Cotter DR. Anti-N-methyl-d-aspartate receptor encephalitis: review of clinical presentation, diagnosis and treatment. BJPsych Bulletin. 2015;39(1):19-23. Doi: https://doi.org/10.1192/pb.bp.113.045518Wilkinson-Smith A, Blackwell LS, Howarth RA. Neuropsychological outcomes in children and adolescents following anti-NMDA receptor encephalitis. Child Neuropsychology. 2022;28(2):212-223. Doi: https://doi.org/10.1080/09297049.2021.1939197Rita CG, Nieto Gaand;ntilde;an I, Jimenez Escrig A, Carrasco Sayalero and;Aacute;. Anti-N-Methyl-D-Aspartate Encephalitis as paraneoplastic manifestation of germ-cell tumours: a case report and literature review. Case Reports in Immunology. 2019;2019(1):1-5. Doi: https://doi.org/10.1155/2019/7014085Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurology. 2011;10(1):63-74. Doi: https://doi.org/10.1016/S1474-4422(10)70253-2Lebon S, Mayor-Dubois C, Popea I, Poloni C, Selvadoray N, Gumy A, Roulet-Perez E. Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis mimicking a primary psychiatric disorder in an adolescent. Journal of Child Neurology. 2012;27(12):1607-1610. Doi: https://doi.org/10.1177/0883073812451325Nosadini M, Eyre M, Molteni E, Thomas T, Irani SR, Dalmau J, Dale RC, Lim M, Anlar B, Armangue T, Benseler S. Use and safety of immunotherapeutic management of N-methyl-D-aspartate receptor antibody encephalitis: a meta-analysis. JAMA Neurology. 2021;78(11):1333-1344. Doi: https://doi.org/10.1001/jamaneurol.2021.3187Guan HZ, Ren HT, Cui LY. Autoimmune encephalitis: an expanding frontier of neuroimmunology. Chinese Medical Journal. 2016;129(9):1122-1127. Doi: https://doi.org/10.4103/0366-6999.180518